While we eat larger quantities and more varieties of foods than any other society today, Americans experience a higher incidence of over-consumptive malnutrition than any other society due to the prevalence of over-processing our foods thus removing vital nutrients, poor farming practices that rob soil of vital nutrients, and consuming "fake" foods with little or no nutritional value. White bread, refined sugar and colas are the centerpieces of the average child’s diet. Consequently, obesity and overweightedness are prevalent in over 60% of the entire American population.

NR-GIZE PLus is a combination of essential fatty acids, vitamins, minerals, amino acids and specialty nutrients designed to give your body what it needs to function at an optimal level. It contains nutrients that enhance your body’s ability to convert hidden, empty calories into useable energy. At the same time, NR-GIZE PLus decreases the chances of carbohydrates and fats not utilized for immediate energy from being further stored in the body as fat by inhibiting the processes leading to fat storage. NR-GIZE PLus also contains nutrients vital to the energy producing pathways of cellular metabolism. These nutrients function as transport mechanisms, coenzymes to cellular reactions, electron and proton donors to drive reactions, cellular detoxicants and cell regulators. NR-GIZE PLus truly works at the cellular level to enhance every possible aspect of cellular metabolism and energy production. Following is a breakdown of the primary nutrients in NR-GIZE PLus and their contribution to the overall function of NR-GIZE PLus. As you will see, each nutrient within NR-GIZE PLus has a specific biological function that works in synergy with every other nutrient in the complete formula. It is this reason that NR-GIZE PLus is the most effective metabolic enhancement product available.

Conjugated Linoleic Acid is an essential fatty acid that has been shown to increase the utilization of stored body fat for the production of cellular energy. Research has shown that CLA increases the active transport of fats, essential nutrients and pure water through the cell wall and into the cell’s mitochondria. CLA also stimulates the excretion of toxins produced during cellular metabolism out of cells and thus out of the body making CLA a tremendous antioxidant as well. By enhancing the activity of the cell membranes of lean muscle cells to allow fats and other essential nutrients into these cells, we can naturally elevate our body’s natural production of energy. People on diets high in CLA also show greater activity of the enzymes involved in the delivery of fats to muscle cells while the enzymes responsible for fat storage are inhibited. This forces fat to instantly be utilized upon ingestion rather than being stored for use at later date. CLA has been shown to increase the amount of glucose shuttled into the cells of muscle and connective tissues for energy utilization rather than being converted to fat and stored as fat. This makes CLA an ideal supplement for people who want to maintain healthy blood sugar levels. 

Super Citrimax^TM is an extract of the fruit from the Garcinia cambogia tree. This extract contains a compound called hydroxycitrate, or HCA, that has been shown to inhibit lipogenesis within the body. Lipogenesis is the process by which excess carbohydrates are converted to fat for storage on the body. HCA inhibits lipogenesis through the inhibition of an enzyme called ATP Citrate Lyase, which is required for fatty acid synthesis from carbohydrates. This forces carbohydrates to either be used immediately for energy or excreted from the body.

Collagen is the primary structural protein of connective tissues, including skin, cartilage, tendons and ligaments within the body. Consuming a predigested collagen protein provides the body with amino acids that dramatically improve the ability of the body to heal itself properly. The specific amino acids high in collagen are proline, hydroxyproline and glycine. The proper formation of collagen in the body is dependent upon adequate Vitamin C intake. Inadequate collagen formation is associated with impaired wound healing, capillary fragility, poor skin and nail health and compromised joint strength. The process of aging decreases efficiencies of collagen production in the body. Supplementation with collagen protein and Vitamin C can improve efficiencies of collagen production and positively affect the aging process.

Pyrucine^TM is a proprietary pyruvate-glycinate complex that enhances cellular respiration (the production of energy at the cellular level). Proper cellular energy production requires tremendous amounts of fuel to drive the biochemical reactions involved in producing ATP for cellular energy. This fuel is found in the form of fat stored on the body, which is shuttled into the mitochondria of each and every cell. Mitochondria can be compared to little engines that burn fuel to create the energy (ATP) necessary for optimal cellular function. In order for the cell to fulfill its energy producing obligations, the mitochondria must also have a good supply of all the necessary co-factors, precursors and coenzymes required to produce energy. Pyruvate is one such co-factor critical to mitochondrial metabolism. In the mitochondria, pyruvate is oxidized to acetyl CoA by the enzyme pyruvate dehydrogenase. The acetyl CoA then enters the Kreb’s cycle where it ultimately ends up, through a series of additional reactions, as ATP. Besides playing a direct role in ATP production, supplementation with pyruvate also improves the transport of glucose into muscle cells for increased energy and endurance.

MSM, also known as methylsulfonylmethane, is a natural organic form of the essential mineral sulfur that is tremendously biologically active. MSM supports healthy connective tissue such as tendons, ligaments, cartilage, and muscle fibers by helping to normalize pressure inside these cells and also by removing the damaging free radicals and toxins that are the major cause of inflammation within connective tissue cells. MSM increases cell wall permeability, which allows water and important nutrients to enter into the cell forcing out these toxins and free radicals further inhibiting damage to tissues. MSM also helps thicken hair follicles, improve skin tone and strengthen nails. Organic sulfur is a major component necessary for the production of the proteins that form hair, skin and nails. The combination of MSM, vitamin C and collagen has shown tremendous benefit in people experiencing skin problems such as premature aging, wrinkling and acne.

Chromium Polynicotinate is a form of niacin-chelated chromium that has significantly increased bioavailability and biological activity. The patented ChromeMate^TM niacin bound chromium has been shown to be 18-times more biologically active than other forms of niacin-bound chromiums, 672% more active than chromium chloride and 311% more active than chromium picolinate. Chromium works in the body by enhancing the activity of insulin in the uptake and metabolism of blood sugar. Through this mechanism of action, chromium has been shown to regulate blood sugar, which is very important for those who experience sugar cravings.

Coenzyme Q10 is a biochemical that is present in the mitochondria of every cell in the human body. CoQ10 is so vital to cellular function that a deficiency of CoQ10 leads to severely diminished energy production and eventually cellular destruction if levels are not adequate. It is vitally important to the functioning of a healthy heart.  The conversion of carbohydrates and fats into energy in the mitochondria requires the presence of CoQ10 in the inner mitochondrial membrane. CoQ10s mechanism of action is as an electron transport instrument in the production of ATP during oxidative phosphorylation in the mitochondria for cellular energy. Studies have demonstrated that CoQ10 plays a direct role in regulating the mitochondrial capacity for forming ATP. Coenzyme Q10 also plays an important role as an antioxidant protecting membrane proteins and DNA from oxidative damage during the conversion of fats to energy ("lipid peroxidation"). Adequate levels of the cofactor nutrient vitamin B6 are necessary for proper Coenzyme Q10 synthesis and function in the body.

L-Carnitine acts as a key that opens the gate of energy flow into most cells. The role of L-Carnitine in fatty acid transfer across mitochondrial membranes to generate ATP has a major influence on the most dominant central energy pathway. It is in this pathway that L-Carnitine works directly with Coenzyme Q10 in producing ATP from fatty acids. In order for these fatty acids to be oxidized into ATP, they first must be transported across a mitochondrial membrane that does not allow easy entry into the mitochondria. The entry is accomplished by attachment of these fatty acids to L-Carnitine, which then can open the mitochondrial membrane to deposit the fatty acid into the mitochondria for oxidation. Vitamin C, Vitamin B6 and Vitamin B3 are all necessary cofactors in L-Carnitine function.

Vitamin B3 is a water-soluble vitamin available in 2 predominant forms, Niacin and Niacinamide. They are both precursors of the coenzymes NAD and NADP. More than 200 different enzymes require these two coenzymes to accept or donate electrons for redox reactions. NAD functions primarily in the catabolism of carbohydrates, fats and proteins to produce energy.

Vitamin B6 and its coenzyme form, pyridoxal-5-phosphate (PLP), are critical to the function of more than 100 different enzyme systems involved in amino acid metabolism, the conversion of fats and carbohydrates to energy and utilization of stored energy sources. PLP functions as a coenzyme for glycogen phosphorylase, an enzyme that catalyzes the release of glycogen stored in muscles for energy. PLP also functions as a coenzyme in the function of heme for hemoglobin production and therefore is critical in oxygen transport. Vitamin B6 is 1/3 of the nutritional triad of Vitamins B6, B12 and Folic Acid responsible for controlling homocysteine levels in the blood. B6 works by converting homocysteine to the amino acid cysteine while B12 and Folic Acid convert homocysteine to methionine.

Vitamin B12, or cyanocobalamin, is a water-soluble vitamin needed in only microgram amounts. It is the largest and most complex of all vitamins. Consequently, it is also the most difficult to absorb. B12 absorption is primarily dependent upon the presence of intrinsic factor but can also be absorbed by passive diffusion. Taking B12 in a complex of nutrients designed to enhance nutrient absorption can have a tremendous effect on enhancing absorption and optimizing biological levels of B12. Vitamin B12 is also 1/3 of the nutritional triad responsible for neutralizing circulating homocysteine and converting it to the amino acid methionine. In this pathway, B12 works with Folic Acid in activating the enzyme methionine synthase, which neutralizes free blood homocysteine and converts it to methionine. Vitamin B12 is also an important coenzyme in the production of energy from fats and proteins through its role in the production of succinyl CoA. Succinyl CoA is also required for the synthesis of hemoglobin in blood.

Folic Acid is a water-soluble vitamin needed in only microgram amounts to be extremely effective. The coenzyme form of folic acid (along with Vitamin B12) is critical to the metabolism of both nucleic acids and amino acids in its action as a methyl donor. DNA and RNA synthesis is dependent on a folate coenzyme that leads to the synthesis of S-adenosylmethionine (SAM), which is a methyl donor in nucleic acid synthesis. In fetal development, adequate folate is critical because of its role in DNA and RNA synthesis. Deficiency of Folic Acid during pregnancy can lead to the neural tube defects anencephaly or spina bifida. Folic Acid is the final 1/3 of the nutritional triad of Vitamins B6, B12 and Folic Acid responsible for controlling blood homocysteine levels.

Vitamin C is a water-soluble vitamin that functions biologically as a reversible biologic reductant. As such, it provides reducing agents for a number of biochemical reactions, is essential as a cofactor in several biochemical reactions requiring a reduced metal ion and is a highly effective antioxidant that can be regenerated in vivo when oxidized. Vitamin C, even in small amounts, can protect vital molecules including proteins, lipids, carbohydrates and nucleic acids from the damaging free radicals produced during cellular metabolism, as well as through exposure to toxicants and environmental pollutants. Vitamin C effectively scavenges hydroxyl, peroxyl and superoxide radicals, as well as reactive peroxide, singlet oxygen and hypochlorite species. Vitamin C also protects against plasma lipid and  cholesterol peroxidation. High levels of Vitamin C in the eyes protect against photolytically generated free radicals as well.

Aloe Vera Gel contains over 75 nutrients and 200 active compounds, including 20 minerals, 18 amino acids, and 12 vitamins. Aloe is a member of the tree lily family and its ethnobotanical name is Aloe barbadensis. It is also known as "lily of the desert", the "plant of immortality", and the "medicine plant". Aloe is said to facilitate digestion, aid in blood and lymphatic circulation, and enhance kidney, liver, and gall bladder function. Aloe contains at least three anti-inflammatory fatty acids that are beneficial to the entire digestive system including the stomach, small intestine and colon. It naturally alkalizes digestive juices to prevent over-acidity, a common cause of indigestion.

Stevia is a small green plant native to Paraguay. Stevia is also known as yerba dulce or "honey leaf". Stevia leaf extract is approximately 80 times sweeter than cane sugar and is used as a natural sweetener to improve the flavor of products it is mixed with. Steviosides and rebaudiosides are the principal constituents found in the leaves of the plant and, when combined with other herbs, enhance the nutritive value of those herbs. Studies have found the leaf to contain proteins, fibers, iron, phosphorus, calcium, potassium, magnesium, zinc, vitamin A, vitamin C and essential oils. Scientific studies have shown that stevia effectively regulates blood sugar and brings it toward a normal balance. Stevia has also been shown to reduce cravings for sweets and fatty foods.

NR-GIZE PLus is formulated with a number of other cofactors that enhance the overall activity of the product. Cofactors work synergistically with the main components of the product increasing uptake and biological activity. It is also produced in a micellized liquid dosage form to increase absorption into the body. Micellized liquid dosage forms have been shown to increase absorption of macromolecules into the body by as much as 500 percent over tablets and capsules.

NR-GIZE PLus contains no artificial colors or flavors, is caffeine and ephedra free, and is manufactured under the strictest guidelines in an FDA inspected and certified GMP and NSF manufacturing facility.

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Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.